ChemDoodle runs on all operating systems, works with all word processors, builds components for all web browsers, and integrates with mobile apps.

No matter the task, ChemDoodle is available

It is essential in this age to be able to interact with individuals from around the world. ChemDoodle allows you to interact with them, regardless of the tools that they use. No matter the chemical sketcher, no matter the operating system, no matter the word processor, ChemDoodle provides you with the tools to communicate.

Operating Systems

We fully support ChemDoodle on Windows, macOS and Linux.

High DPI Support

ChemDoodle completely supports high resolution displays, such as Retina Macs and the Microsoft Surface Pro.


Control interface colors, interface font sizes, define cursors and a cursor left-handed and right-handed mode make it comfortable for most users to use the software. You can also fully define all of the menu item accelerators (except the ones forced by the operating system) and tool shortcuts.

Word Processors

ChemDoodle can paste scalable vector graphics into your favorite word processors, including Microsoft Office, Apple iWork and OpenOffice.

Round-trip Editing

Round-trip editing allows you to insert content into 3rd party applications, and then place that same content back into ChemDoodle from that 3rd party application for further editing. Round-trip editing is supported on Windows through OLE, macOS via PDF and on Linux with OpenOffice.*

Quicklook Plugin

A Quicklook plugin for macOS allows you to preview all of the chemical formats ChemDoodle understands conveniently in Finder. Not on Mac? No worries, ChemDoodle’s file chooser contains previews on all operating systems.


ChemDoodle allows you to produce interactive HTML5 components that work in Microsoft Internet Explorer and Edge, Mozilla Firefox, Google Chrome, Apple Safari and Opera, and even on Mobile Safari on iOS and Chrome for Android.

Mobile Devices

ChemDoodle has mobile companions for iOS (iPod/iPhone/iPad) and Android.

3rd Party Integration

ChemDoodle works with several partners to help you improve your workflow. These partners include databases like ChemExper and ChemSpider, ELNs such as LabArchives and social networking services like Twitter.

Chemical Style Sheets

ChemDoodle provides a number of predefined chemical style sheets to create styled graphics specifically for certain journals, including Nature and ACS Document 1996. You can also create and share your own style sheets to make creating books and other projects easier when groups are involved.

Chemical Applications

ChemDoodle reads and writes 30 popular chemical file types for working with the applications you use.

  1. ACD/ChemSketch Documents (.sk2)
  2. ChemDoodle Documents (.icl)
  3. ChemDoodle 3D Scenes (.ic3)
  4. ChemDoodle Javascript Data (.cwc.js)
  5. CambridgeSoft ChemDraw Exchange (.cdx)
  6. CambridgeSoft ChemDraw XML (.cdxml)
  7. Crystallographic Information Format (.cif)
  8. CHARMM CARD File (.crd)
  9. ChemAxon Marvin Document (.mrv)
  10. Chemical Markup Language (.cml)
  11. Daylight SMILES (.smi, .smiles)
  12. IUPAC InChI (.inchi)
  13. IUPAC JCAMP-DX (.jdx, .dx)
  14. ISIS Sketch File (.skc)
  15. ISIS Sketch Transportable Graphics File (.tgf)
  16. MDL MOLFiles, both V2000 and V3000 connection tables (.mol, .mdl)
  17. MDL SDFiles (.sdf, .sd)
  18. MDL RDFiles (.rdf, .rd)
  19. MDL RXNFiles, both V2000 and V3000 connection tables (.rxn)
  20. MMI SketchEl Molecule (.el)
  21. Molinspiration JME String (.jme)
  22. RCSB MacroMolecular Transmission Format (.mmtf)
  23. RCSB Protein Data Bank Files (.pdb, .ent)
  24. Schrödinger MacroModel (.mmd, .mmod)
  25. Schrödinger Maestro (.mae)
  26. Standard Molecular Data (.smd)
  27. Tripos Mol2 (.mol2, .ml2, .sy2)
  28. Tripos Sybyl Line Notation (.sln)
  29. Beilstein ROSDAL (.ros)
  30. XYZ Files (.xyz)


ChemDoodle writes a large number of bitmap and vector graphics for use with other graphics applications. Most of our vector formats allow for text to shape conversion (compatibility) or preserving text output (for future editing, such as in LaTeX document creation).


  1. CompuServ Graphics Interchange Format {.gif}
  2. Joint Photographic Experts Group {.jpg, .jpeg, .jpe, .jfif, .jfi, .jif}
  3. Microsoft Bitmap {.bmp, .dib}
  4. Portable Network Graphics {.png}
  5. Tagged Image File Format {.tiff, .tif}
  6. UNIX Portable PixMap {.ppm, pnm, pbm, pgm}
  7. Wireless Bitmap {.wbmp}


  1. Adobe Portable Document Format {.pdf}
  2. Encapsulated Postscript {.eps, .epi, .epsi, .epsf}
  3. Macintosh Vector Pict {.pict}
  4. OpenDocument Graphics {.odg}
  5. Web Scalable Vector Graphics {.svg, .svgz}
  6. Windows Enhanced Metafile {.emf}

*It takes two applications to work together for round trip editing. While ChemDoodle provides functionality for round trip editing, the other application you want to round trip with may not support round trip editing. Other applications that do support round trip editing may remove round trip editing functionality at any time and without the consent of iChemLabs.